City Therapeutics
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Founders
About
City Therapeutics is a Cambridge, Massachusetts-based biotechnology company developing next-generation RNA interference (RNAi) therapeutics 12. The company is advancing an RNAi engineering platform with multiple programs, including an ongoing Phase 1 clinical trial of CITY-FXI and additional pipeline programs (including CITY-RBP4 for Stargardt disease) progressing toward the clinic by year-end 2026 12. The company is led by CEO Andy Orth and was co-founded by John Maraganore (former Alnylam CEO), who serves as Executive Chairman 12.
Funding History
| Date | Round | Amount | Lead | Co-investors |
|---|---|---|---|---|
| 2026-06-09 | Series B | $99.5M | Viking Global Investors, Sofinnova Investments | Casdin Capital, NYBC Ventures, ARCH Venture Partners, Fidelity Management & Research Company, Invus, Slate Path Capital, Rock Springs Capital, Regeneron Ventures, AN Ventures 123 |
Following the Series B, the company has raised more than $230M in total 1. Rohan Nirody (Viking Global) and Maha Radhakrishnan (Sofinnova) joined the board of directors as observers 12.
What Investors Say
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What Founders Say
No independently sourced founder quotes have been verified at this time.
Sources
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“City Therapeutics Announces $99.5 Million Series B Financing to Advance Next-Generation RNAi Therapeutics,” BusinessWire, June 8, 2026. Accessed June 2026. https://www.businesswire.com/news/home/20260608486606/en/City-Therapeutics-Announces-$99.5-Million-Series-B-Financing-to-Advance-Next-Generation-RNAi-Therapeutics↩↩↩↩↩↩
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“City Therapeutics Raises $99.5 Million Series B to Advance Next-Generation RNAi Therapies,” Pulse 2.0, June 9, 2026. Accessed June 2026. https://pulse2.com/city-therapeutics-raises-99-5-million-series-b-to-advance-next-generation-rnai-therapies/amp/↩↩↩↩↩
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“City Therapeutics Raises $99.5M in Series B Funding,” FinSMEs, June 2026. Accessed June 2026. https://www.finsmes.com/2026/06/city-therapeutics-raises-99-5m-in-series-b-funding.html↩